PUBLICATION IN THE PRESTIGIOUS JOURNAL OF CLINICAL INVESTIGATIONS ON THE DISCOVERY OF CD4 ANERGY / CD4 LYMPHOPENIA IN HIV PATIENTS ****** Discovery of a new mechanism of immune pathogenesis involving a phospholipase which becomes pathogenic for CD4+ T-cells in the presence of a viral peptide (cofactor) This new pathophysiological mechanism regulates the activity of CD4+ T-cells, the orchestrator of the immune system This article also describes a therapeutic monoclonal antibody to treat CD4+ anergy…